Paper Details: Downloads: 390
Serial Number: P1160819002
Title: Modeling and Analysis of Glucose-Insulin Oscillatory System
Authors: Fadhl M. Al-Akwaa and Khaled Wahba and Abdalla S.A Mohamed
Abstract: A system dynamics model of the glucose Regulatory feedback system in man is used to understand the mechanisms underlying ultradian oscillations of insulin secretion and glucose levels. We show that the Glucose-Insulin, Glucose-Glucagon and the Insulin-Glucagon feedback loops are significantly important to produce these oscillations. The model confirms that the occurrence and properties of the oscillations were found to be critically dependent on the two delays between the insulin concentration and the subsequent effect on glucose production and glucose utilization. Our simulations further suggest that the number of plasma insulin and insulin secretion pulses was significantly lower in diabetic patients because of the broken of glucose-insulin and insulinglucose feedback loop in those patients. The model was validated via several kinds of test inputs (glucose injections and infusions, insulin injections and infusions, etc.), and was compared its behaviour with the experimenta
Keywords: The Dynamic of Glucose-Insulin Endocrine Regulatory System
Journal/Conference: International Journal of Bioinformatics and Medical Engineering
Volume: 8
Issue: 1
Submission Date: 5/7/2008 12:00:00 AM
Review Date: 6/21/2008 12:00:00 AM
Publishing Date: 10/4/2008 12:00:00 AM
Article Downloads: 390
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